发明名称 |
MEMBRANE TYPE-1 MATRIX METALLOPROTEIN INHIBITORS AND USES THEREOF |
摘要 |
<p>Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.</p> |
申请公布号 |
EP2373789(A4) |
申请公布日期 |
2012.08.29 |
申请号 |
EP20090832788 |
申请日期 |
2009.12.17 |
申请人 |
ANGIOCHEM INC. |
发明人 |
BELIVEAU, RICHARD;GINGRAS, DENIS;NYALENDO, CARINE |
分类号 |
C12N9/64;A61K38/10;A61K38/48;A61K38/57;A61P19/02;A61P35/00;C07K14/81 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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