| 摘要 |
The present invention provides hypoallergenic polypeptides comprising or consisting of a variant of the amino acid sequence of SEQ ID NO: 1 wherein one or more amino acids of SEQ 1 within an IgE-binding epitope is mutated and wherein the polypeptide exhibits reduced IgE-reactivity compared to a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1. The invention further provides pharmaceutical compositions of such polypeptides, as well as methods for making and using said polypeptides, for example in the prevention of pollen grass allergies. Related aspects of the invention provide antibody polypeptides for passive immunisation against pollen grass allergies. |
