发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE DERIVATIVES OF 2-(2-PYRIDYLMETHYLSULFINYL)-BENZIMIDAZOLE VIA INCLUSION COMPLEX WITH 1,1'-BINAPHTHALENE-2, 2'DIOL |
摘要 |
Process for the preparation of optically active derivatives of 2-(2-piridylmethylsulfinyl)-benzimidazole, or salts thereof, by resolution of the corresponding racemic derivatives of 2-(2-piridylmethylsulfinyl)-benzimidazole. The resolution is performed through the formation of inclusion complexes with (S)-(-) or (R)-(+)-[1,1'-Binaphthalene]-2,2'-diol in the presence of an amine, followed by the break of the inclusion complex by treatment with an hydroxide of an alkaline metal. The enantiomer of the derivative of 2-(2-piridylmethylsulfinyl)-benzimidazole may be obtained by extractions at a particular pH with a suitable organic solvent. The process allows to perform the resolution with high yields and high optical purity, without using neither toxic solvents nor chromatography.
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申请公布号 |
CA2598224(C) |
申请公布日期 |
2012.08.28 |
申请号 |
CA20062598224 |
申请日期 |
2006.02.22 |
申请人 |
ESTEVE QUIMICA, S.A. |
发明人 |
COPPI, LAURA;BERENGUER MAIMO, RAMON;GASANZ GUILLEN, YOLANDA;MEDRANO RUPEREZ, JORGE |
分类号 |
C07D401/12;A61K31/4439;A61P1/04 |
主分类号 |
C07D401/12 |
代理机构 |
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主权项 |
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地址 |
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