CELL THERAPY COMPOSITION FOR PREVENTING OR TREATING GRAFT-VERSUS-HOST DISEASE COMPRISING MESENCHYMAL STEM CELL AND REGULATORY T CELL

摘要

PURPOSE: A cell therapy composition for preventing or treating graft-versus-host diseases including immune-modulating T cells and mesenchymal stem cells is provided to control rejection against the host after transplanted marrow is engrafted, thereby reducing the generation of the graft-versus-host diseases. CONSTITUTION: A cell therapy composition for preventing or treating graft-versus-host diseases includes immune-modulating T cells and mesenchymal stem cells. The mesenchymal stem cell is a human derivative mesenchymal stem cell. The immune-modulating T cell is an immune-modulating T cell which is induced by retinal. The immune-modulated T cell is CD4+CD25+ immune-modulated T cell which is induced by processing retinal, anti-CD3, TGF-b, and anti-CD28 on the CD4+ T cell. The composition includes 1×10^4 cell/kg-1×10^8 cell/kg of the Cell Therapy Products.