发明名称 |
Fremgangsmåde til humanisering af antistoffer og humaniserede antistoffer opnået derved |
摘要 |
A humanized anti-NGF antibody or a fragment thereof which maintains binding activity to NGF, wherein the humanized anti-NGF antibody comprises,
(a) a VH region having a first CDR comprising the amino acid sequence GFSLTNNNVNW, a second CDR comprising the amino acid sequence GVWAGGATDYNSALKS, and a third CDR comprising the amino acid sequence DGGYSSSTLYAMDA; and
(b) a VL region having a first CDR comrising the amino acid sequence RASEDIYNALA, a second CDR comprising the amino acid sequence HT, and a third CDR sequence comprising the amino acid sequence QHYFHYPRT. |
申请公布号 |
DK1709076(T3) |
申请公布日期 |
2012.08.27 |
申请号 |
DK20040806887T |
申请日期 |
2004.12.23 |
申请人 |
LAY LINE GENOMICS SPA;S.I.S.S.A. SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI |
发明人 |
CATTANEO, ANTONINO;COVACEUSZACH, SONIA;LAMBA, DORIANO |
分类号 |
C07K16/00;C07K16/22;C07K16/28;C07K16/46;G06F19/00;G06F19/16 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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