摘要 |
FIELD: chemistry. ^ SUBSTANCE: present invention relates to heterocyclic compounds of formula (I), where R1 represents C1-6 alkyl, optionally substituted with hydroxy, monocyclic C3-8 cycloaliphatic radical, optionally substituted with hydroxy, or phenyl; R2 represents H, C1-6 alkyl, optionally substituted with hydroxy or morpholine, monocyclic C3-8 cycloaliphatic radical, optionally substituted with a hydroxy group or a heterocycloaliphatic radical, where the heterocycloaliphatic radical is piperidine, pyrrolidine or morpholine; each of a, a', b and c independently represents N or C(R3); each of R3, R5 and R6 independently represents H, halogen, phenyl, substituted with one substitute selected from methoxy methyl, amino, methoxy or trifluoromethoxy, or heteroaryl substituted with alkyl, hydroxy or alkoxy; R4 represents H; K represents -N(RX')-; J represents a bond, -O, alkylene, -C(O)-, -C(O)-O-, or -C(O)-N(Rx')-; RX' represents H; n equals 0; and under the condition that if R1 represents an unsubstituted alkyl, J represents -O-, then R2 represents H. The invention also relates to a pharmaceutical composition based on a compound of formula (I). ^ EFFECT: obtaining novel heterocyclic compounds, useful as modulators of interleukin receptor-associated kinase IRAK. ^ 20 cl, 18 ex |