NEW CATECHIN DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING CATECHIN DERIVATIVE, USING CATECHIN DERIVATIVE AND USING PHARMACEUTICAL COMPOSITION

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention offers compounds presented by general formula (I): or their pharmaceutically acceptable salts wherein R1, R2, R3 and R4 are presented in the description and exhibit substantial COMT inhobotory activity. Besides, the present invention described pharmaceutical compositions inhibiting catechol-O-transferase activity which contain the compound or its pharmaceutically acceptable salt as an active ingredient, and a pharmaceutically acceptable carrier. ^ EFFECT: there are declared pharmaceutical combinations for treatment or prevention of Parkinson's disease which contain (1) the pharmaceutical composition containing the compound under any cl 1-8 or its pharmaceutically acceptable salt and the pharmaceutically acceptable carrier, and (2) at least one compound specified in L-dope or carbidole. ^ 10 cl, 9 ex, 17 tbl