| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, oncology, and may be used for treating squamous cell cancer of anal canal. The therapy is two-staged. The first stage involves radiation teletherapy in a dynamic dose fractionation mode with the paratumoural introduction of chemopreparations. The remote teletherapy is preceded by anaesthesia from 2 sides in a lateral direction from rectal walls at the distance of 3-4 cm at conditional 9 and 3 o'clock and at the depth of 8-10 cm behind M. Levatoris ani. As chemopreparations, 5-fluorouracil and methotrexate are administered sequentially via the same injection canals in standard calculated doses 4 times every second day. Thereafter 2-3 days later, it is followed by the remote teletherapy according to the dynamic dose fractionation schedule. Before the radiation, the similar anaesthesia is provided in enlarged fractions, and metronidazole is administered paratumourally at 2-3 mg/cm3 of the tumour. The second stage follows after a 2-week pause and involves endoluminal brachytherapy. ^ EFFECT: implementing the method enables higher clinical effectiveness and reduced toxic load on the patient's body ensured by the targeted administration of the preparation and possibility to achieve a high concentration in a loci-regional system of the tumour. ^ 2 ex |
