| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method for anantioselective production of an acetate salt of methyl ester of (2R,3S)-3-phenylisoserine of formula (I), which is a structural element suitable for use in synthesis of taxane derivatives. The method involves the following steps: a) treating racemic treo-3-phenylisoserine amide (VI) with an enantiomerically pure acid to obtain the corresponding salt formed from (2R,3S)-3-phenylisoserine amide and acid; b) treating the salt formed from (2R,3S)-3-phenylisoserine amide and acid with a strong inorganic acid in a protonic solvent to obtain a salt formed from (2R,3S)-3-phenylisoserine amide and inorganic acid; c) treating the salt formed from (2R,3S)-3-phenylisoserine amide and inorganic acid with hydrochloric acid in a protonic solvent with subsequent treatment with acetic acid to crystallise an acetate salt of methyl ester of (2R,3S)-3-phenylisoserine amide. The invention also relates to an intermediate compound, specifically (2R,3S)-3-phenylisoserine amide in form of a salt of (-) dibenzoyl tartaric acid. ^ EFFECT: method for enantioselective production of an acetate salt of methyl ester of (2R,3S)-3-phenylisoserine amide of formula (I). ^ 4 cl, 6 ex |
