发明名称 |
PREGNANOLONE DERIVATIVES SUBSTITUTED IN 3ALPHA-POSITION WITH THE CATIONIC GROUP, METHOD OF THEIR PRODUCTION, USAGE AND PHARMACEUTICAL PREPARATION INVOLVING THEM |
摘要 |
The presented invention applies to pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, the method of the production of these compounds and their utilization for treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post traumatic stress dissorder, and other diseases related to stress, anxiety, schizophrenia, and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy, and gliomas. The object of invention is also the use of compounds of general formula I for production of veterinary and human pharmaceutical preparation for treatment of above mentioned diseases and for production of pharmaceutical preparations containing these compounds. |
申请公布号 |
WO2012110010(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
WO2012CZ00016 |
申请日期 |
2012.02.15 |
申请人 |
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I.;FYZIOLOGICKY USTAV AKADEMIE VED CESKE;CHODOUNSKA, HANA;KAPRAS, VOJTECH;VYKLICKY, LADISLAV;BOROVSKA, JIRINA;VYKLICKY, VOJTECH;VALES, KAREL;STUCHLIK, ALES;RAMBOUSEK, LUKAS |
发明人 |
CHODOUNSKA, HANA;KAPRAS, VOJTECH;VYKLICKY, LADISLAV;BOROVSKA, JIRINA;VYKLICKY, VOJTECH;VALES, KAREL;STUCHLIK, ALES;RAMBOUSEK, LUKAS |
分类号 |
C07J41/00;A61K31/57;A61P25/00;A61P25/24;A61P25/28;C07J75/00 |
主分类号 |
C07J41/00 |
代理机构 |
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