发明名称 |
NOVEL METHOD FOR THE PRODUCTION OF A ANTIMICROBIAL PEPTIDE |
摘要 |
The present invention relates to a method of producing a peptide consisting of the amino acids 63 to 110 of dermcidin (SEQ ID NO: 3) comprising (a) culturing a host cell carrying a nucleic acid molecule encoding the peptide in an expressible form, and (b) optionally isolating the peptide from the culture. Furthermore, the invention relates to a nucleic acid molecule encoding a fusion protein comprising or consisting of (a) a peptide heterologous with regard to dermcidin protein-tag; and, C-terminally thereof (b) a peptide having the antimicrobial activity of dermcidin wherein the fusion protein contains an arginine residue located immediately N-terminally of the peptide of (b).
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申请公布号 |
US2012213764(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
US201013395638 |
申请日期 |
2010.09.22 |
申请人 |
NAUMER CHRISTIAN;KROHN MICHAEL;TIFFERT YVONNE;ECK JUERGEN;B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATIONNETWORK AG |
发明人 |
NAUMER CHRISTIAN;KROHN MICHAEL;TIFFERT YVONNE;ECK JUERGEN |
分类号 |
A61K38/48;A61K8/66;A61P31/00;A61Q19/00;C07H21/04;C07K19/00;C12P21/02;C12P21/06 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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