发明名称 |
SYSTEM FOR DETERMINING UNPROCESSED AND PARTIALLY PROCESSED NEUROTOXIN TYPE A |
摘要 |
The present invention is concerned with tools for the quality control and safety during manufacture of neurotoxins. In particular, it relates to a method for the determination of the amount of partially processed and/or unprocessed Botulinum neurotoxin A polypeptide (BoNT/A) in a solution comprising processed and partially processed and/or unprocessed BoNT/A comprising the steps of contacting a sample of the solution with a capture antibody which specifically binds to the partially processed and unprocessed BoNT/A under conditions which allow for binding of the antibody to the partially processed and unprocessed BoNT/A, whereby a complex is formed, and determining the amount of the formed complex, whereby the amount of the complex is indicative for the amount of the partially processed and/or unprocessed BoNT/A in the solution. Moreover, the present invention contemplates a device and a kit for carrying out the method. |
申请公布号 |
US2012214182(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
US201013503128 |
申请日期 |
2010.10.18 |
申请人 |
TAYLOR HAROLD VICTOR;EISELE KARL-HEINZ;BRUNN CORNELIA;MERZ PHARMA GMBH & CO. KGAA |
发明人 |
TAYLOR HAROLD VICTOR;EISELE KARL-HEINZ;BRUNN CORNELIA |
分类号 |
G01N33/566;C07K16/12;C12M1/40 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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