发明名称 |
STATIN AND OMEGA 3 FATTY ACIDS (EPA, DHA AND DPA) FOR USE IN CARDIOVASCULAR DISEASES |
摘要 |
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight including a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA represent about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition are taught. EPA + DHA are about 80% of the total formulation and about 89% of the total omega 3 fatty acid content of the composition. The formulation may further contain specific amounts of arachidonic acid (AA) and of omega-3 fatty acids having 18 carbon atoms, including one or more of stearidonic acid (SDA) and alpha-linolenic acid (ALA). The application further teaches methods of administering such combinations, and is directed towards unit dosages of such combinations for the reduction of apolipoprotein-B levels. |
申请公布号 |
WO2012112531(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
WO2012US25026 |
申请日期 |
2012.02.14 |
申请人 |
PIVOTAL THERAPEUTICS, INC.;JACKOWSKI, GEORGE;MACSWEENY, RACHELLE;SHAIKH, NISAR;YANTHA, JASON;SCHINI-KERTH, VALERIE |
发明人 |
JACKOWSKI, GEORGE;MACSWEENY, RACHELLE;SHAIKH, NISAR;YANTHA, JASON;SCHINI-KERTH, VALERIE |
分类号 |
A61K31/202;A61K9/00;A61K31/40;A61K45/06 |
主分类号 |
A61K31/202 |
代理机构 |
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