PHARMACEUTICAL COMPOSITION FOR EYE DISEASE CONTAINING SUPEROXIDE DISMUTASE FUSION PROTEIN

摘要

PURPOSE: A pharmaceutical composition containing superoxide dismutase fusion protein is provided to thicken conjunctival epithelium and to reduce corneal injury. CONSTITUTION: An ophthalmic composition for preventing and treating opthalimic diseases contains a fusion protein which is conjugated with protein transducing domains at one or more among N-terminal and C-terminal of superoxide dismutase. The protein transducing domain contains: a protein transducing domain having a hydrophobic domain containing 15-30 amino acids and having 5 or more tryptophan, a hydrophilic domain having 4 or more lysine, and a spacer; a protein transducing domain having 6-12 amino acid residues wherein 3/4 or more of the amino acids are arginine or lysine; an oligolysine protein transducing domain having 6-12 lysine; an oligoarginine protein trasducing domain having 6-12 arginine; or an oligo(lysine,arginine) protein transducing domain having 6-12 lysine or arginine.