SUBSTITUTED 3-(BIPHENYL-3-YL)-8,8-DIFLUORO-4-HYDROXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONES FOR THERAPY

摘要

The invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (1a) for therapeutic purposes, pharmaceutical compositions and use thereof in therapy, especially for prophylaxis and therapy of tumor disorders. The invention also relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as defined above, to several processes and intermediates for preparation thereof and to the use thereof as pesticides and/or herbicides and/or fungicides. The invention also relates to selective herbicidal compositions which comprise firstly halogen-substituted spirocyclic keto-enols and secondly a compound which improves crop plant compatibility. The present invention further relates to the enhancement of the action of crop protection compositions comprising especially halogen-substituted spirocyclic keto-enols by the addition of ammonium or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for production thereof and to the use thereof in crop protection as pesticides and/or fungicides and/or for prevention of unwanted plant growth.