发明名称 |
ALZHEIMER'S DISEASE CELLULAR MODEL FOR DIAGNOSTIC AND THERAPEUTIC DEVELOPMENT |
摘要 |
Stem-cell derived human neuronal models that mimic human Alzheimer's disease, including hereditary and sporadic Alzheimer's disease, comprising neural stem cells derived from human induced pluripotent stem cells. Also provided arc purified human neurons developed from the neural stem cells that carry genomes from the Alzheimer's disease patients. The human neuronal models are neuronal models for hereditary and sporadic Alzheimer's disease, and are suitable for measurement of key behaviors of the Alzheimer's disease, providing further diagnostic tools for the development of sporadic Alzheimer's disease, and assisting in drug testing for the therapeutic treatment of Alzheimer's disease. |
申请公布号 |
WO2012112737(A2) |
申请公布日期 |
2012.08.23 |
申请号 |
WO2012US25354 |
申请日期 |
2012.02.16 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;GOLDSTEIN, LAWRENCE;ISRAEL, MASON |
发明人 |
GOLDSTEIN, LAWRENCE;ISRAEL, MASON |
分类号 |
C12N5/079;C12N5/02;C12N5/0793;G01N33/15;G01N33/68 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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