| 发明名称 |
ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES |
| 摘要 |
The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. |
| 申请公布号 |
US2012213785(A1) |
申请公布日期 |
2012.08.23 |
| 申请号 |
US201213453817 |
申请日期 |
2012.04.23 |
| 申请人 |
LI KANG;ZHOU BIN-BING STEPHEN;WU WENJUAN;FUNG SEK CHUNG;SINGH SANJAYA;GENENTECH, INC. |
发明人 |
LI KANG;ZHOU BIN-BING STEPHEN;WU WENJUAN;FUNG SEK CHUNG;SINGH SANJAYA |
| 分类号 |
A61K39/395;A61P25/06;A61P25/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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代理人 |
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| 主权项 |
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