| 发明名称 |
GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS |
| 摘要 |
Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of Pichia pastoris glycoengineered to produce a GCSF wherein greater than 18% of the molecules comprise an 0-glycan with one mannose per (0-glycan is described. In particular aspects, the GCSF is PEGylated at the JV-terminus.
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| 申请公布号 |
US2012213728(A1) |
申请公布日期 |
2012.08.23 |
| 申请号 |
US201013504528 |
申请日期 |
2010.10.25 |
| 申请人 |
MEEHL MICHAEL;RIOS SANDRA;GOMATHINAYAGAM SUJATHA;LI HUIJUAN;BOBROWICZ PIOTR;MERCK |
发明人 |
MEEHL MICHAEL;RIOS SANDRA;GOMATHINAYAGAM SUJATHA;LI HUIJUAN;BOBROWICZ PIOTR |
| 分类号 |
A61K38/19;C12N1/19;C12N15/62;C12P21/02 |
主分类号 |
A61K38/19 |
| 代理机构 |
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