| 发明名称 |
3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINES |
| 摘要 |
The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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| 申请公布号 |
US2012214806(A1) |
申请公布日期 |
2012.08.23 |
| 申请号 |
US201213460905 |
申请日期 |
2012.05.01 |
| 申请人 |
ANDREINI MATTEO;BANNER DAVID;GABELLIERI EMANUELE;GUBA WOLFGANG;HILPERT HANS;MAUSER HARALD;MAYWEG ALEXANDER V.;NARQUIZIAN ROBERT;POWER EOIN;ROGERS-EVANS MARK;TRAVAGLI MASSIMILIANO;VALACCHI MICHELA;WOLTERING THOMAS;WOSTL WOLFGANG |
发明人 |
ANDREINI MATTEO;BANNER DAVID;GABELLIERI EMANUELE;GUBA WOLFGANG;HILPERT HANS;MAUSER HARALD;MAYWEG ALEXANDER V.;NARQUIZIAN ROBERT;POWER EOIN;ROGERS-EVANS MARK;TRAVAGLI MASSIMILIANO;VALACCHI MICHELA;WOLTERING THOMAS;WOSTL WOLFGANG |
| 分类号 |
A61K31/5377;A61K31/5375;A61P1/00;A61P3/00;A61P3/10;A61P5/16;A61P7/02;A61P9/10;A61P17/00;A61P19/02;A61P19/04;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P37/00;C07D265/30;C07D265/32;C07D413/12;C07D413/14;C07D417/12;C07D471/04 |
主分类号 |
A61K31/5377 |
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