AN IMPROVED PROCESS FOR PREPARATION OF LEVONORGESTREL
摘要
<p>The present invention provides an improved process for preparation of levonorgestrel (3) which comprises of hydrolysis of 13 ß-ethyl-3-methoxy-17a-ethynyl-gona-2,5(10)-dien-17ß- o1 (2) with an acid in aprotic solvent. The present invention also provides a novel process for purification of crude levonorgestrel (3) by recrystallization from N,N-dimethyl formamide- water; methanol-water mixture.</p>
申请公布号
WO2012110947(A1)
申请公布日期
2012.08.23
申请号
WO2012IB50658
申请日期
2012.02.14
申请人
LUPIN LIMITED;ZADBUKE, SWAPNIL, AJIT;MEHARE, KISHOR, GULABRAO;GODBOLE, HIMANSHU, MADHAV;SINGH, GIRIJ, PAL
发明人
ZADBUKE, SWAPNIL, AJIT;MEHARE, KISHOR, GULABRAO;GODBOLE, HIMANSHU, MADHAV;SINGH, GIRIJ, PAL
