发明名称 |
GABA RELEASE-REGULATING AGENT IN CEREBELLUM |
摘要 |
A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.
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申请公布号 |
US2012214742(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
US201013389981 |
申请日期 |
2010.08.24 |
申请人 |
LEE CHANGJOON JUSTIN;LEE SOO-JUNG;YOON BO-EUN |
发明人 |
LEE CHANGJOON JUSTIN;LEE SOO-JUNG;YOON BO-EUN |
分类号 |
A61K38/08;A61K31/196;A61K31/26;A61K31/44;A61K31/7105;A61K38/17;A61K48/00;A61P25/00;A61P25/08;A61P25/28;A61P25/32;B01L3/00;C07C229/66;C07C331/30;C07D213/80;C07H21/02;C07H21/04;C07K7/18;G01R27/28 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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