发明名称 |
Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders |
摘要 |
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. |
申请公布号 |
EP2489733(A2) |
申请公布日期 |
2012.08.22 |
申请号 |
EP20120152550 |
申请日期 |
2007.06.07 |
申请人 |
GENZYME CORPORATION |
发明人 |
DODGE, JAMES;SHIHABUDDIN, LAMYA;O'RIORDAN, CATHERINE R. |
分类号 |
C12N15/00;A01K67/027;A61K48/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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