发明名称 |
EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR |
摘要 |
The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of an allosteric inhibitor. |
申请公布号 |
KR20120093146(A) |
申请公布日期 |
2012.08.22 |
申请号 |
KR20127002920 |
申请日期 |
2010.07.02 |
申请人 |
SANOFI;VRIJE UNIVERSITEIT BRUSSEL;LIFE SCIENCES RESEARCH PARTNERS VZW;VIB VZW |
发明人 |
CARMELIET PETER;DE SMET FREDERIK;SCHYMKOWITZ JOOST;ROUSSEAU FREDERIC;HERBERT CORENTIN |
分类号 |
C07K14/71;A61K31/4745 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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