| 摘要 |
A solid form (A) of an anti-EGFR (epidermal growth factor receptor) antibody (Ab) and/or its variants and/or fragments, that, when dissolved or suspended in aqueous medium generates biologically active Ab protein, is new, where (A) is prepared by precipitation of Ab, dissolving or suspending in aqueous medium, using a precipitation agent (B), optionally followed by separating the precipitate. - ACTIVITY : Cytostatic; Antidiabetic; Ophthalmological; Antiinflammatory; Antipsoriatic; Antirheumatic; Antiarthritic; Vulnerary; Immunosuppressive; Immunostimulator; Vasotropic. No details of tests for these activities are given. - MECHANISM OF ACTION : Inhibiting binding of ligands (specifically epidermal growth factor) to EGFR and inhibiting EGFR-mediated signal transduction, resulting in inhibition of cell proliferation; Reduction in tumor-associated angiogenesis; Induction of apoptosis and increased effects for radiation and chemical therapy.
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