| 发明名称 |
Modified lecithin-cholesterol acyltransferase enzymes |
| 摘要 |
<p>The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.</p> |
| 申请公布号 |
EP2489731(A1) |
申请公布日期 |
2012.08.22 |
| 申请号 |
EP20120003811 |
申请日期 |
2008.07.25 |
| 申请人 |
AMGEN, INC |
发明人 |
ZHOU, MINGYUE;BOONE, THOMAS CHARLES;MEININGER, DAVID PARK;SCHWARZ, MARGIT;SHAN, BEI;SHEN, WENYAN |
| 分类号 |
C12N9/10;A61K38/45 |
主分类号 |
C12N9/10 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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