摘要 |
<p>The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2-carboxylic acid and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salts of L-alanine and L-valine prodrugs of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.</p> |
申请人 |
WOCKHARDT LIMITED;PATEL, MAHESH V.;DESAI, VIJAYA N.;DESHPANDE, PRASAD K;YEOLE, RAVINDRA DATTATRAYA;KALE, RAJESH PRABHAKAR |
发明人 |
PATEL, MAHESH, VITHALBHAI;DESAI, VIJAYA, NARAYAN;DESHPANDE, PRASAD, KESHAV;YEOLE, RAVINDRA, DATTATRYA;KALE, RAJESH, PRABHAKAR |