N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
摘要
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
申请公布号
EP2489350(A1)
申请公布日期
2012.08.22
申请号
EP20120155608
申请日期
2007.03.16
申请人
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;CARDIOXYL PHARMACEUTICALS, INC.