发明名称 |
Alpha 1-acid glycoprotein, alpha 2-HS glycoprotein, alpha 1-antitrypsin, and fragments thereof induce apoptosis in cancer cell lines |
摘要 |
This invention characterizes the selective apoptotic activity of specially prepared zinc charged alpha 1-acid glycoprotein, alpha 2-HS glycoprotein, and alpha 1-antitrypsin. These proteins cause apoptosis in cancer cells while leaving normal cells intact. In addition, active fragments of zinc charged alpha 1-acid glycoprotein and alpha 2-HS glycoprotein, whether manufactured from the modification of natural alpha 1-acid glycoprotein or alpha 2-HS glycoprotein, recombinantly, or synthetically, selectively induce apoptosis.
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申请公布号 |
US8247380(B2) |
申请公布日期 |
2012.08.21 |
申请号 |
US20090389319 |
申请日期 |
2009.02.19 |
申请人 |
TSAI DAVID;AMBRYX BIOTECHNOLOGY, D.C. |
发明人 |
TSAI DAVID |
分类号 |
A61P35/00;A61K35/16;A61K38/00;A61K38/17;A61K38/57;C07K14/00 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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