发明名称 |
Optical amplification of molecular interactions using liquid crystals |
摘要 |
Interactions between molecules that are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The invention provides for a method for detecting an analyte, comprising contacting with said analyte a recognition moiety for said analyte, wherein said contacting causes at least a portion of a plurality of mesogens proximate to said recognition moiety to detectably switch from a first orientation to a second orientation upon contacting said analyte with said recognition moiety; and detecting said second orientation of said at least a portion of said plurality of mesogens, whereby said analyte is detected.
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申请公布号 |
US8246911(B2) |
申请公布日期 |
2012.08.21 |
申请号 |
US20020044899 |
申请日期 |
2002.01.09 |
申请人 |
ABBOTT NICHOLAS L.;SKAIFE JUSTIN J.;GUPTA VINAY K.;DUBROVSKY TIMOTHY B.;SHAH RAHUL;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ABBOTT NICHOLAS L.;SKAIFE JUSTIN J.;GUPTA VINAY K.;DUBROVSKY TIMOTHY B.;SHAH RAHUL |
分类号 |
G01N21/75;G01N33/543;G01N27/00;G01N33/53;G02F1/13;G02F1/1337 |
主分类号 |
G01N21/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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