发明名称 |
ANTIBIOTIC 107891, ITS FACTORS, PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOSITIONS, AND USE THEREOF |
摘要 |
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M . catharralis, Neisseria species and H. influenzae and Mycobacteria. |
申请公布号 |
PT1848731(E) |
申请公布日期 |
2012.08.20 |
申请号 |
PT20050712250T |
申请日期 |
2005.01.27 |
申请人 |
SENTINELLA PHARMACEUTICALS, INC. ( SENTINELLA ) |
发明人 |
AMERIGA LAZZARINI;LUCIANO GASTALDO;GIANPAOLO CANDIANI;ISMAELA CICILIATO;DANIELE LOSI;FLAVIA MARINELLI;ENRICO SELVA;FRANCO PARENTI |
分类号 |
C07K14/195;A23K20/195;A61K38/12;A61K38/16;C07K7/64;C07K14/00;C12P1/06 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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