METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HCV INFECTIONS

摘要

The present invention relates to uses, methods and compositions for treating an infection by a member of the Flaviviridae family, such as HCV, in a subject in need thereof. More particularly, the prevention invention relates to an agent effective to inhibit the binding of a HCV envelope glycoprotein (E1 or E2) to CD229 protein present on the surface of hepatocytes o an inhibitor of CD229 gene expression for use in the treatment of an HCV infection or for use in the treatment of a disease associated with an HCV infection in a subject in need thereof, such as acute or chronic hepatitis C or for use to prevent a subject from contracting HCV or for use in the prevention of liver diseases, such as liver fibrosis, liver cirrhosis or hepatocellular carcinoma.