CELLULAR TARGETS OF THIAZOLIDINEDIONES

摘要

A method for identifying a lead candidate compound that is effective in treating or preventing an insulin-resistance disease or disorder in a subject comprises:screening one or more candidate compounds in a binding assay, the binding assay comprising the steps: (i) providing an mTOT protein; (ii) contacting the mTOT protein with a candidate compound; and (iii) detecting if the candidate compound specifically binds to the mTOT protein or inhibits the specific binding of a thiazolidinedione compound to the mTOT protein. The candidate compound is identified as a lead candidate compound if the candidate compound specifically binds to the mTOT protein or inhibits the binding of the thiazolidinedione compound to the mTOT protein.