发明名称 |
PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE |
摘要 |
The invention relates to compounds of general formula (I): wherein: each of R1 and R9 is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: -H, C1-4alkyl, C2-4alkenyl, and halogenated C1-4alkyl; and wherein: each of RA and RB is independently selected from: C1-4alkyl, halogenated C1-4alkyl, and C6-10aryl; or RA and RB are linked to form a group selected from: C1-6 alkylene and C6-10 arylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts. |
申请公布号 |
CA2827027(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
CA20112827027 |
申请日期 |
2011.08.15 |
申请人 |
WISTA LABORATORIES LTD. |
发明人 |
CLUNAS, SCOTT;STOREY, JOHN MERVYN DAVID;SINCLAIR, JAMES PETER;BADDELEY, THOMAS CRAVEN;ISHAQ, AHTSHAM;SIMPSON, MICHAEL;WILLIAMSON, CRAIG;WOOD, BARRY ALAN;WISCHIK, CLAUDE MICHEL;HARRINGTON, CHARLES ROBERT;RICKARD, JANET ELIZABETH;HORSLEY, DAVID;LOH, YIN SZE;MARSHALL, COLIN;KHAN, KARRAR AHMAD |
分类号 |
C07D279/20;A61K31/5415;A61P25/00 |
主分类号 |
C07D279/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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