COMPOSITIONS AND METHODS FOR NANOPOLYMER-BASED NUCLEIC ACID DELIVERY
摘要
Provided herein are p-GlcNAc nanoparticle/nucleic acid compositions. In one aspect, the p-GlcNAc nanoparticle/nucleic acid compositions comprise deacetylated poly-N- acetylglucosamine lactate derivative nanoparticles less than 500 nm and a nucleic acid. Also, provided herein are methods for administering a nucleic acid to a subject, the method comprising administering to the subject a p-GlcNAc nanoparticle/nucleic acid composition. In certain embodiments, the p-GlcNAc nanoparticle/nucleic acid composition is administered subcutaneous ly to the subject.
申请公布号
WO2012061803(A3)
申请公布日期
2012.08.16
申请号
WO2011US59558
申请日期
2011.11.07
申请人
MARINE POLYMER TECHNOLOGIES, INC.;VOURNAKIS, JOHN, N.;DEMCHEVA, MARINA, V.