| 发明名称 |
G-PROTEIN-COUPLED RECEPTOR AGONIST |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel compound useful as an agonist of G-protein-coupled receptors (GPCR). <P>SOLUTION: The G-protein-coupled receptor agonist includes a compound represented by general formula: L-(CH<SB POS="POST">2</SB>)m-COOH or its pharmaceutically acceptable salt. In the general formula: L is R<SP POS="POST">1</SP>R<SP POS="POST">2</SP>N- or R<SP POS="POST">1</SP>O-; R<SP POS="POST">1</SP>is an aromatic hydrocarbon group which may be substituted; R<SP POS="POST">2</SP>is an aromatic hydrocarbon group which may be substituted, a hydrogen atom or the like; R<SP POS="POST">1</SP>and R<SP POS="POST">2</SP>may form a ring together; m is 4-16;-CH<SB POS="POST">2</SB>CH<SB POS="POST">2</SB>- not including the terminus C atom of -(CH2)m- may be substituted by -MR<SP POS="POST">3</SP>-; M is O, S or NR<SP POS="POST">4</SP>; R<SP POS="POST">3</SP>is a 1-5C alkylene group which may be substituted or the like; and R<SP POS="POST">4</SP>is an aromatic hydrocarbon group which may be substituted, an aromatic heterocyclic group which may be substituted, a hydrogen atom or the like. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012153679(A) |
申请公布日期 |
2012.08.16 |
| 申请号 |
JP20110016446 |
申请日期 |
2011.01.28 |
| 申请人 |
KYOTO UNIV;NAGOYA CITY UNIV;PHARMA FRONTIER KK |
发明人 |
TSUJIMOTO GOZO;HIRASAWA AKIRA;MIYATA NAOKI;SUZUKI TAKAYOSHI;HIRANO TATSUYA;TAKAHARA YOSHIYUKI |
| 分类号 |
C07C59/68;A61K31/196;A61K31/20;A61K31/403;A61K31/423;A61K31/426;A61K31/428;A61K31/437;A61K31/4402;A61K31/444;A61K31/47;A61K31/472;A61K31/538;A61K31/5415;A61P3/10;A61P43/00;C07C217/18;C07C229/34;C07D209/86;C07D213/74;C07D215/38;C07D217/22;C07D263/58;C07D265/38;C07D277/20;C07D277/42;C07D277/82;C07D279/36;C07D471/04 |
主分类号 |
C07C59/68 |
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