发明名称 |
VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME |
摘要 |
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject. |
申请公布号 |
WO2012109570(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
WO2012US24702 |
申请日期 |
2012.02.10 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;ASOKAN, ARAVIND;PULICHERLA, NAGESH |
发明人 |
ASOKAN, ARAVIND;PULICHERLA, NAGESH |
分类号 |
C07K14/075;A61P3/00;A61P9/00;A61P21/00;C12N15/861 |
主分类号 |
C07K14/075 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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