OLIGOMER PROBE ARRAY WITH IMPROVED SIGNAL-TO-NOISE RATIO AND DETECTION SENSITIVITY AND METHOD OF MANUFACTURING THE SAME

摘要

An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity even when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and being coupled with at least one oligomer probe with its own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.