发明名称 |
SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER |
摘要 |
The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.
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申请公布号 |
US2012207817(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
US201113027038 |
申请日期 |
2011.02.14 |
申请人 |
LEE CHIA-HWA;HUANG CHING-SHUI;CHEN CHING-SHYANG;TU SHIH-HSIN;WANG YING-JAN;CHANG YU-JIA;TAM KA-WAI;WEI PO-LI;CHENG TZU-CHUN;CHU JAN-SHOW;CHEN LI-CHING;WU CHIH-HSIUNG;HO YUAN-SOON;TAIPEI MEDICAL UNIVERSITY |
发明人 |
LEE CHIA-HWA;HUANG CHING-SHUI;CHEN CHING-SHYANG;TU SHIH-HSIN;WANG YING-JAN;CHANG YU-JIA;TAM KA-WAI;WEI PO-LI;CHENG TZU-CHUN;CHU JAN-SHOW;CHEN LI-CHING;WU CHIH-HSIUNG;HO YUAN-SOON |
分类号 |
A61K9/127;A61K31/34;A61K31/4355;A61K31/437;A61K31/4439;A61K31/713;A61P35/00;C07H21/00;C07H21/02;C12Q1/18;C12Q1/68 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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地址 |
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