发明名称 |
PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS |
摘要 |
<p>Tracers targeting phosphodiesterase1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.</p> |
申请公布号 |
EP2485771(A1) |
申请公布日期 |
2012.08.15 |
申请号 |
EP20100822355 |
申请日期 |
2010.10.07 |
申请人 |
INTRA-CELLULAR THERAPIES, INC. |
发明人 |
LI, PENG;WENNOGLE, LAWRENCE, P.;ZHAO, JUN;ZHENG, HAILIN |
分类号 |
A61K51/00;A61K51/04;A61M36/14 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|