The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.
申请公布号
EP1556701(B1)
申请公布日期
2012.08.15
申请号
EP20030809343
申请日期
2003.10.21
申请人
ROCHE MTM LABORATORIES AG
发明人
RIDDER, RUEDIGER;REICHERT, ANJA;TRUNK-GEHMACHER, MARCUS;BATRLA, RICHARD