发明名称 |
SMALL MOLECULE INHIBITORS OF NECROPTOSIS |
摘要 |
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-±) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (I)-(I), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-± induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role. |
申请公布号 |
EP2381775(A4) |
申请公布日期 |
2012.08.15 |
申请号 |
EP20090835866 |
申请日期 |
2009.12.23 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
YUAN, JUNYING;HSU, EMILY, S. |
分类号 |
A61K31/519;A61K31/045;A61K31/415;A61K31/4178;A61K31/429;A61K31/496;A61K31/517;A61P35/00;C07D231/06;C07D231/12;C07D231/56;C07D277/46;C07D403/12;C07D417/12;C07D495/04;C07D498/08 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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