发明名称 |
ARTIFICIAL BASE PAIR CAPABLE OF FORMING SPECIFIC BASE PAIR |
摘要 |
<p>The present invention provides a double-stranded nucleic acid in which at least one nucleic acid strand includes an unnatural base that forms a self-complementary base pair or an unnatural base that forms a base pair with any natural base with substantially the same thermal stability. The present invention also provides a method of hybridizing a first nucleic acid strand with a second nucleic acid strand, wherein the first nucleic acid strand includes an unnatural base that forms a self-complementary base pair or an unnatural base that forms a base pair with any natural base with substantially the same thermal stability, and a method of applying the nucleic acid to SNP detection, a DNA chip, DNA/RNA computing, or an in vitro translation system. The present invention provides a method of introducing an unnatural base into a nucleic acid strand and thereby controlling the thermodynamic stability in hybridization of the nucleic acid strand.</p> |
申请公布号 |
EP2487181(A1) |
申请公布日期 |
2012.08.15 |
申请号 |
EP20100822055 |
申请日期 |
2010.10.06 |
申请人 |
RIKEN;TAGCYX BIOTECHNOLOGIES |
发明人 |
HIRAO, ICHIRO;HIRAO, MICHIKO;YOKOYAMA, SHIGEYUKI |
分类号 |
C07H21/02;C07H19/23;C07H19/24;C07H21/04;C12M1/00;C12N15/09;C12P21/02;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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