| 摘要 |
The ether of phenyl p-methoxyphenyl carbinol and b -dimethylaminoethanol is prepared by heating phenyl p-methoxyphenyl carbinol with b -dimethylamino halogeno-ethane. The sodium derivative of the carbinol may be employed instead of the free carbinol. A haloid salt of the b -dimethylamino halogeno ethane may be used in the above reaction in the presence of sodamide. One example is given in which the hydrochloride salt of the above ether is also prepared. Specifications 585,994 and 670,570 are referred to. b -Dimethylaminochloroethane is prepared by reacting thionyl chloride in benzene with b -dimethylaminoethanol. The Specification as open to inspection under Sect. 91 refers to the preparation of ethers of the general formula <FORM:0685524/IV (b)/1> and mineral and organic salts thereof, by a method similar to that employed in the accepted Specification. The groups Ar, Ar1 and Ar11 may represent any of the group C6H5-, p-CH3C6 H4-, p-CH3OC6H4-, or C10H7-or Ar may represent hydrogen, Ar1 any of the above groups and Ar11 any of the group p-CH3C6H4-, p-CH3OC6H4-, or C10H7-, or one of the groups Ar, Ar1 and Ar11 represents a heterocyclic group, e.g. a pyridyl group, and the remaining groups may be any of the groups referred to above, and Z represents two methyl or ethyl radicals or the residue <FORM:0685524/IV (b)/2> or <FORM:0685524/IV (b)/3> Additional examples refer to the preparation of the ether of di-(p-methoxyphenyl) and b - dimethylaminoethanol and its hydrochloride salt, the ether of 2-pyridyl phenyl carbinol and b -dimethylaminoethanol and its hydrochloride salt, and the ether of 2-pyridyl p-methoxyphenyl carbinol and b -dimethylaminoethanol and its salts derived from hydrochloric, 2,4-dihydroxybenzoic, boric and fumaric acids. 2-Pyridyl phenyl carbinol is prepared by reacting benzaldehyde and magnesium 2-pyridyl bromide, or by the decarboxylation of picolinic acid in the presence of benzaldehyde. 2-Pyridyl p-methoxyphenyl carbinol is prepared by reacting anisaldehyde and magnesium 2-pyridyl bromide, or by the decarboxylation of picolinic acid in the presence of anisaldehyde. This subject-matter does not appear in the Specification as accepted. |
