发明名称 |
GENETICALLY MODIFIED MICE AND ENGRAFTMENT |
摘要 |
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia. |
申请公布号 |
EP2485583(A2) |
申请公布日期 |
2012.08.15 |
申请号 |
EP20100822486 |
申请日期 |
2010.10.04 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;YALE UNIVERSITY;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB) |
发明人 |
STEVENS, SEAN;MURPHY, ANDREW J.;FLAVELL, RICHARD;EYNON, ELIZABETH;GALAN, JORGE;WILLINGER, TIM;MANZ, MARKUS, G.;RONGVAUX, ANTHONY;YANCOPOULOS, GEORGE D. |
分类号 |
A01K67/027;A61K49/00;C07K14/52;C07K14/535;C07K14/54;C07K14/715;C12N9/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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