发明名称 Amphiphilic molecule, molecular assembly comprising the amphiphilic molecule, and use of the molecular assembly
摘要 The present invention provides an amphiphilic molecule having a plurality of zwitterionic functional groups in its hydrophilic moiety and a molecular assembly comprising the amphiphilic molecule as a constituent lipid. The molecular assembly of the present invention forms a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when it is deformed under an acidic pH environment. The molecular assembly of the present invention can be used as a carrier for a drug, a probe, a nucleic acid, a protein or the like.
申请公布号 US8241647(B2) 申请公布日期 2012.08.14
申请号 US20080451555 申请日期 2008.05.16
申请人 TAKEOKA SHINJI;OBATA YOSUKE;TAJIMA SHOJI;ITO MANABU;MIZUNO ATSUSHI;NISHIYAMA NATSUKO;TAKEUCHI YOSHITO;WASEDA UNIVERSITY;JCR PHARMACEUTICALS CO. LTD. 发明人 TAKEOKA SHINJI;OBATA YOSUKE;TAJIMA SHOJI;ITO MANABU;MIZUNO ATSUSHI;NISHIYAMA NATSUKO;TAKEUCHI YOSHITO
分类号 A61K9/00;C08G69/26 主分类号 A61K9/00
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