| 摘要 |
PURPOSE: A solid dispersion containing amorphous selecoxib is provided to ensure excellent elusion rate and storage stability and to be applied to a solid pharmaceutical composition for oral administration. CONSTITUTION: A solid dispersion contains 100 parts by weight of selecoxib, 20-60 parts by weight of water soluble polymers, and 5-30 parts by weight of surfactant. The surfactant is sodium lauryl sulfate. The solid dispersion additionally contains 1-5 parts of by weight of organic acid. The organic acid includes citric acid, tartaric acid, malic acid, succinic acid, acetic acid, sorbic acid, adipic acid, formic acid, furmaric acid, or gluconic acid. A pharmaceutical composition for selectively suppressing cyclooxygenase-2(COX-2) contains the solid dispersion as an active ingredient. A pharmaceutical composition for preventing or treating pain or inflammatory diseases contains the solid dispersion as an active ingredient.
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