发明名称 |
Method for detecting rheumatoid arthritis-specific autoantibodies |
摘要 |
A method for detecting anti-filaggrin-autoantibodies specific to rheumatoid arthritis in a biological sample, by providing a filaggrin with no citrulline residues (FNC) having an arginine residue or a filaggrin peptide with no citrulline residues (PFNC) having an arginine residue. Also provided are a citrulline-containing filaggrin (FC) having the peptide sequence of the FNC where some arginine residues have been converted to citrulline residues or a citrulline-containing peptide (PFC) having the peptide sequence of the PFNC, where at least one arginine residue has been converted to a citrulline residue. The sample is contacted with the FNC or PFNC and the FC or PFC, and the resulting immune complexes are detected and quantified, with a value XNC and XC, respectively. Anti-filaggrin-autoantibodies specific to rheumatoid arthritis are determined to be present in the biological sample if the value of XC is greater than the value of XNC. |
申请公布号 |
US8241856(B2) |
申请公布日期 |
2012.08.14 |
申请号 |
US20040479571 |
申请日期 |
2004.01.20 |
申请人 |
INCAURGARAT BRIGITTE;JOLIVET MICHEL;LETOURNEUR ODILE;NOGUEIRA MARIA LEONOR;SEBBAG MIREILLE;SERRE GUY;VINCENT CHRISTIAN;BIOMERIEUX |
发明人 |
INCAURGARAT BRIGITTE;JOLIVET MICHEL;LETOURNEUR ODILE;NOGUEIRA MARIA LEONOR;SEBBAG MIREILLE;SERRE GUY;VINCENT CHRISTIAN |
分类号 |
G01N33/53;A61K38/00;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K17/00;G01N33/564 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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