发明名称 |
Induction of an immune response against dengue virus using the prime-boost approach |
摘要 |
The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprises administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins. |
申请公布号 |
US8241638(B2) |
申请公布日期 |
2012.08.14 |
申请号 |
US20070982488 |
申请日期 |
2007.11.02 |
申请人 |
SIMMONS MONIKA;PORTER KEVIN R.;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
SIMMONS MONIKA;PORTER KEVIN R. |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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