发明名称 |
DPI FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN |
摘要 |
An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physiochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delievered by DPI when SAE-CD is used as a carrier. |
申请公布号 |
KR20120089705(A) |
申请公布日期 |
2012.08.13 |
申请号 |
KR20127011393 |
申请日期 |
2005.04.22 |
申请人 |
CYDEX PHARMACEUTICALS, INC. |
发明人 |
PIPKIN JAMES D.;ZIMMERER RUPERT O.;HICKEY ANTHONY J.;THOMPSON DIANE O.;SMYTH HUGH D. C. |
分类号 |
A61K31/721;A61K9/00;A61K9/14;A61K9/16;A61K47/40 |
主分类号 |
A61K31/721 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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