发明名称 DIHYDRO ISO CA-4 ET ANALOGUES : PUISSANTS CYTOTOXIQUES, INHIBITEURS DE LA POLYMERISATION DE LA TUBULINE
摘要 <p>The present invention relates to compounds of formula (I) below in which:—R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms,—R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms,—A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle,—X represents a nitrogen atom or a CH group, and—Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and—Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a—CN,—SO2NR12R13,—SO2R9,—COOR15 or—COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.</p>
申请公布号 FR2932180(B1) 申请公布日期 2012.08.10
申请号 FR20080053694 申请日期 2008.06.04
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS 发明人 ALAMI MOUAD;MESSAOUDI SAMIR;HAMZE ABDALLAH;PROVOT OLIVIER;BRION JEAN DANIEL;LIU JIAN MIAO;BIGNON JEROME;BAKALA JOHANNA
分类号 C07D317/54;A61K31/09;A61K31/136;A61K31/27;A61K31/403;A61P17/06;A61P35/00;C07C39/10;C07C211/55;C07C271/12;C07C271/18;C07D209/12 主分类号 C07D317/54
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